Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway

Regulation of Mat Responses by a Differentiation MAPK Pathway in Saccharomyces cerevisiae

Fungal species exhibit diverse behaviors when presented with extracellular challenges. Pathogenic fungi can undergo cell differentiation and biofilm formation in response to fluctuating nutrient levels, and these responses are required for virulence. In the model fungal eukaryote Saccharomyces cerevisiae, nutrient limitation induces filamentous growth and biofilm/mat formation. Both responses r...

p85α REGULATES OSTEOBLAST DIFFERENTIATION BY CROSS- TALKING WITH MAPK PATHWAY

From Department of Pediatrics 1 , Herman B Wells Center for Pediatric Research 2 , Department of Biochemistry and Molecular Biology 3 ; Department of Anatomy and Cell Biology 4 , Indiana University School of Medicine; Indianapolis, Indiana 46202; Running title: p85α and mesenchymal stem cells * Correspondence author: Feng-Chun Yang, Indiana University School of Medicine, Cancer Research Institu...

Therapeutic potential of genistein in ovariectomy-induced pancreatic injury in diabetic rats: The regulation of MAPK pathway and apoptosis

Objective(s): Genistein, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of genistein on proteins involved in β-cell proliferation, survival and apoptosis to further reveal its anti-diabetic potential in the ovariectomized diabetic rat. Materials and Methods: We used three-month-...

Regulation of p38 MAPK by MAPK Kinases

Multiple Signals Converge on a Differentiation MAPK Pathway

An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentiation response that occurs under specific environmental conditions. To identify new aspects of filamentous growth regulation, we used a novel screen...